منابع مشابه
Hepatology Elsewhere
The pathogenesis of nonalcoholic steatohepatitis (NASH) is poorly defined. Feeding mice a diet deficient in methionine and choline (MCD diet) induces experimental NASH. Osteopontin (OPN) is a Th1 cytokine that plays an important role in several fibroinflammatory diseases. We examined the role of OPN in the development of experimental NASH. A/J mice were fed MCD or control diet for up to 12 wk, ...
متن کاملHEPATOLOGY Elsewhere
Cholestasis, or impaired bile flow, is an important but poorly understood manifestation of liver disease. Two clinically distinct forms of inherited cholestasis, benign recurrent intrahepatic cholestasis (BRIC) and progressive familial intrahepatic cholestasis type 1 (PFIC1), were previously mapped to 18q21. Haplotype analysis narrowed the candidate region for both diseases to the same interval...
متن کاملHepatology Elsewhere
The ezrin-radixin-moesin (ERM) family of proteins crosslink actin filaments and integral membrane proteins. Radixin (encoded by Rdx) is the dominant ERM protein in the liver of wildtype mice and is concentrated at bile canalicular membranes (BCMs). Here we show that Rdx( / ) mice are normal at birth, but their serum concentrations of conjugated bilirubin begin to increase gradually around 4 wee...
متن کاملHEPATOLOGY Ekewhere Elsewhere Reviews THERAPY OF ACUTE HEPATITIS C WITH INTERFERON HOW GOOD IS IT
To test whether interferon can prevent acute non-A, non-B hepatitis from becoming chronic, a prospective controlled trial was conducted in 26 patients; 11 were treated for an average of 30 days with a mean of 52 megaunits of interferon and 14 acted as controls. 4 patients in the treatment group who continued to have raised serum aminotransferase concentrations after a year’s follow-up were give...
متن کاملHepatology Highlights.
Correspondence and reprint request: Prof. Nahum Méndez-Sánchez, MD, MSc, PhD, FACG, AGAF. Liver Research Unit, Medica Sur Clinic & Foundation Puente de Piedra 150, Col. Toriello Guerra, Mexico City, Mexico. Telephone: +525-554247200 (4215); Fax: +525-55666-4031 E-mail: [email protected] Outcome of early vs. deferred antiviral treatment for recurrent hepatitis C in liver transplant recipi...
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ژورنال
عنوان ژورنال: Journal of Clinical and Experimental Hepatology
سال: 2011
ISSN: 0973-6883
DOI: 10.1016/s0973-6883(11)60113-8